GHK-CU

GHK‑Cu is a naturally occurring tripeptide (glycyl‑L‑histidyl‑L‑lysine) that forms a stable complex with copper (II) ions. It was originally isolated from human plasma and is known to support tissue repair and regenerative pathways. Mechanistically, GHK‑Cu enhances collagen and elastin gene expression, promotes angiogenesis, up‑regulates antioxidant enzyme activity, and modulates extracellular‑matrix remodeling — making it a compelling research candidate for cellular repair, skin rejuvenation and connective‑tissue regeneration.

For research use only. Not for human or veterinary therapeutic use.

Being studied for:

Skin regeneration & anti‑aging: promotes collagen/elastin synthesis, improves skin firmness and elasticity, reduces fine lines and photo‑damage.

Wound healing & tissue repair: enhances re‑epithelialization, granulation tissue formation, and fibroblast activation in animal/in vitro models.

Anti‑inflammatory effects: suppresses pro‑inflammatory cytokines (e.g., TNF‑α, IL‑6) and modulates NF‑κB/p38‑MAPK signaling pathways in injury models.

Antioxidant / oxidative‑stress protection: stimulates antioxidant enzymes (e.g., SOD), neutralizes reactive carbonyl species and protects cells from UV/oxidative damage.

Angiogenesis & extracellular‑matrix (ECM) modulation: up‑regulates factors such as VEGF, modulates metalloproteinases (MMPs) and enhances ECM structural integrity.